The reference site for Cisapride

Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract.

WHAT IS CISAPRIDE?

Cisapride is used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn.

It works by increasing the rate at which your esophagus, stomach, and intestines move during digestion. It also increases the rate at which your stomach empties into your intestines and increases the strength of your lower esophageal sphincter (the muscle between your stomach and your esophagus).

 

Brand Name(s): Propulsid
CAS nº: 81098-60-4
(SIS-a-pride)

 

Product Info

The sections below will provide you with more specific information and guidelines related to cisapride and its correct use. Please read them carefully.

FDA Information

Cisapride was approved by FDA in tablet form in 1993, and then in suspension form in 1995.

Cisapride is a treatment for severe nighttime heartburn in patients with gastroesophageal reflux disease (GERD) who do not adequately respond to other therapies. Measures are being recommended to help physicians avoid giving cisapride to patients at known risk of rare, but serious, cardiac events associated with the drug.

In many countries it has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias, about which the FDA issued a warning letter to health care professionals and patients.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Cisapride is used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn.

This medication works by increasing the rate at which your esophagus, stomach, and intestines move during digestion. It also increases the rate at which your stomach empties into your intestines and increases the strength of your lower esophageal sphincter (the muscle between your stomach and your esophagus).

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Cisapride comes as a tablet and liquid form to be taken by mouth.

Take cisapride exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Shake the liquid well before measuring a dose. To ensure that you get a correct dose, measure the liquid form of cisapride with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Cisapride is usually taken four times a day, at least 15 minutes before meals and at bedtime.

Do not consume grapefruit or grapefruit juice while taking cisapride. Grapefruit products may increase amount of cisapride available in your body, which could lead to dangerous side effects.

What special precautions should I follow?

BEFORE TAKING CISAPRIDE:

Do not take cisapride if you have heart disease or hardening of the arteries, heart failure, an irregular heartbeat or a history of irregular heartbeats, a history of prolonged QT intervals, a family history of congenital long QT syndrome, a slow heart rate that is considered a medical condition, a structural heart defect, heart block or other conduction disturbances, severe dehydration (loss of water), vomiting, malnutrition, an eating disorder, or kidney failure. These conditions may increase the risk of irregular heartbeats, heart attack, and death while taking cisapride.

Furthermore, do not take cisapride with any of the following drugs: antibiotics such as clarithromycin (Biaxin®), erythromycin (Ery-Tab®, E.E.S.®, E-Mycin®, others), troleandomycin (TAO®), and sparfloxacin (Zagam®); antidepressants such as amitriptyline (Elavil®), maprotiline (Ludiomil®), and nefazodone (Serzone®); antifungal medications such as fluconazole (Diflucan®), itraconazole (Sporanox®), and ketoconazole (Nizoral®); phenothiazines such as prochlorperazine (Compazine®, others) and promethazine (Phenergan®, others); antihistamines such as astemizole (Hismanal®); blood pressure medications such as bepridil (Vascor®); heart medications such as procainamide (Procan SR®, Procanbid®, Pronestyl®) and quinidine (Quinidex®, Quinaglute®); and HIV medications such as indinavir (Crixivan®) and ritonavir (Norvir®). Taken with any of these drugs, cisapride may cause irregular heartbeats that could lead to death. Nevertheless, this is not a complete list of drugs that may interact with cisapride and cause heart problems. Talk to your doctor or pharmacist before taking any other medications.

Additionally, cisapride is in the FDA pregnancy category C. This means that it is not known whether cisapride will harm an unborn baby. Do not take cisapride without first talking to your doctor if you are pregnant.

Furthermore, cisapride passes into breast milk. It is not known whether cisapride will harm a nursing infant. Do not take cisapride without first talking to your doctor if you are breast-feeding a baby.

Use alcohol in moderation. Alcohol may increase drowsiness and dizziness while you are taking cisapride.

Do not consume grapefruit or grapefruit juice while taking cisapride. Grapefruit products may increase amount of cisapride available in your body, which could lead to dangerous side effects.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose.

Never take a double dose of this medication.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking cisapride and seek emergency medical attention or notify your doctor immediately:

an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives)
fainting
fast or irregular heartbeats

Other, less serious side effects may be more likely to occur. Continue to take cisapride and talk to your doctor if you experience:

abdominal pain
nausea
diarrhea
increased frequency of urination

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed. If it is necessary, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services on 911.

Symptoms of overdose may include:

nausea
vomiting
rumbling noises in the stomach
flatulence
diarrhea
urinary frequency
tremors
seizures
weakness

Product Images

PICTURES OF CISAPRIDE MEDICATION

Below you will find images and specific information on the principal types of cisapride that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PROPULSID®
Strength(s): 1 MG / ML
Imprint: Propulsid Suspension
Manufacturer: JANSSEN PHARMACEUTICAL INC.

Name: PROPULSID®
Strength(s): 1 MG / ML
Imprint: Propulsid Syrup
Manufacturer: CIZA

Name: PROPULSID®
Strength(s): 20 MG
Imprint: JANSSEN | P 20
Manufacturer: JANSSEN PHARMACEUTICAL INC.

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